反应详情

Water (1.5 ml) and 1.5 ml of conc. hydrochloric acid were added to 432 mg of α-methylthio-α-(m-phenoxyphenyl)propionic acid, and then 300 mg of zinc powder was added. With stirring, the mixture was heated under reflux for 2.5 hours. Water (10 ml) and 30 ml of diethyl ether were added to the reaction mixture. The insoluble matter was separated by filtration. The filtrate was extracted three times with 80 ml of diethyl ether. The organic layer was washed with 10 ml of water, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to afford 364 mg of α-(m-phenoxyphenyl)propionic acid as an oil. The yield was 100%.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 2.5 hours
3. customThe insoluble matter was separated by filtration
4. extractionThe filtrate was extracted three times with 80 ml of diethyl ether
5. washThe organic layer was washed with 10 ml of water
6. dry with materialdried over anhydrous sodium sulfate
7. customThe solvent was removed under reduced pressure