Hydrochloric Acid → HCID 178479214, compound

HRID 614289Notes

Reaction equation

HRID 614289 reaction equation
C[O-].[Na+].[Cl:4][CH2:5][C:6]#[N:7].[NH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1.Cl>CO>[ClH:4].[Cl:4][CH2:5][C:6]([NH:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1)=[NH:7]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 7856ChloroacetonitrileHCID 763102-AminoindaneHCID 10942334Sodium Methoxide

Product 1

HCID 178479214HCID 178479214, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a stirred solution of 0.54 g. (0.01 mole) of sodium methoxide in 100 ml. methanol was added 7.6 g. (0.1 mole) chloroacetonitrile with cooling. The solution was stirred at room temperature for 1 1/2 hours. Then there was added a solution of 10.9 g. (0.1 mole) of 2-aminoindane in 50 ml. of methanol and 16.66 ml. of 6N ethanolic hydrochloric acid (0.1 mole). The solution was stirred at room temperature for 4 hours and concentrated to dryness at room temperature under high vacuum. The product was recrystallized from isopropanol.

Workup

  1. additionThen there was added a solution of 10.9 g
  2. stirringThe solution was stirred at room temperature for 4 hours
  3. concentrationconcentrated to dryness at room temperature under high vacuum
  4. customThe product was recrystallized from isopropanol

Sources & evidence

ORD record
ord-2cee5df31f0543faaa4f23d1dd122d72
Source dataset
uspto-grants-1979_03
Patent number
US04144271

Reaction notes

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