Phenyl chloroformate → phenyl N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyrimidinyl)carbamate hydrochloride

HRID 614320Notes

Reaction equation

HRID 614320 reaction equation
[CH:1]([N:4]([CH:16]([CH3:18])[CH3:17])[CH2:5][CH2:6][NH:7][C:8]1[N:13]=[C:12]([CH3:14])[CH:11]=[C:10]([CH3:15])[N:9]=1)([CH3:3])[CH3:2].[Cl:19][C:20]([O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:21]>C1C=CC=CC=1>[ClH:19].[CH:16]([N:4]([CH:1]([CH3:2])[CH3:3])[CH2:5][CH2:6][N:7]([C:8]1[N:9]=[C:10]([CH3:15])[CH:11]=[C:12]([CH3:14])[N:13]=1)[C:20](=[O:21])[O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([CH3:18])[CH3:17]

Participants

4

Reactant 2

HCID 15891Phenyl chloroformateHCID 233499002-(2-Diisopropylaminoethylamino)-4,6-dimethylpyrimidine

Product 1

HCID 21329151phenyl N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyrimidinyl)carbamate hydrochloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

A solution of 2-(2-diisopropylaminoethylamino)-4,6-dimethylpyrimidine (12.5 g., 0.05 mole) in 50 ml of benzene is added to a solution of phenyl chloroformate in 50 ml of benzene. After 72 hours, the solid product is collected and recrystallized from acetone to give phenyl N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyrimidinyl)carbamate hydrochloride melting at 190°-202° C.

Workup

  1. customthe solid product is collected
  2. customrecrystallized from acetone

Sources & evidence

ORD record
ord-161798b1ca10448ca0d4f240f911854d
Source dataset
uspto-grants-1979_03
Patent number
US04144338

Reaction notes

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