Sodium Hydroxide → HCID 23349886, compound

HRID 614323Notes

Reaction equation

HRID 614323 reaction equation
[CH3:1][N:2]([CH3:14])[CH2:3][CH2:4][N:5]([C:8]1[CH:13]=[N:12][CH:11]=[CH:10][N:9]=1)[C:6]#[N:7].[OH-:15].[Na+]>Cl>[CH3:1][N:2]([CH3:14])[CH2:3][CH2:4][N:5]([C:8]1[CH:13]=[N:12][CH:11]=[CH:10][N:9]=1)[C:6]([NH2:7])=[O:15]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23349877HCID 23349877, compound

Product 1

HCID 23349886HCID 23349886, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

N-(2-Dimethylaminoethyl)-N-(2-pyrazinyl)cyanamide (2.83 g., 0.015 mole) is dissolved in 20 ml of 6N hydrochloric acid. After one hour, the mixture is made alkaline with concentrated sodium hydroxide and concentrated. The residue is extracted with ether which is concentrated. The residue is crystallized from butyl chloride and N-(2-dimethylaminoethyl)-N-(2-pyrazinyl)urea melting at 105°-108° C. is obtained.

Workup

  1. concentrationconcentrated
  2. extractionThe residue is extracted with ether which
  3. concentrationis concentrated
  4. customThe residue is crystallized from butyl chloride

Sources & evidence

ORD record
ord-908c74050e8746788049ca31a04cc073
Source dataset
uspto-grants-1979_03
Patent number
US04144338

Reaction notes

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