Thionyl Chloride → HCID 86736398, compound

HRID 614330Notes

Reaction equation

HRID 614330 reaction equation
[Cl:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[S:9](Cl)(Cl)=[O:10]>CCOCC>[Cl:1][C:2]1[C:7]([N:8]=[S:9]=[O:10])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 805282-Chloro-3-pyridylamine

Product 1

HCID 86736398HCID 86736398, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 2-chloro-3-aminopyridine (12.9 g, 0.1 m) and thionyl chloride (5.5 g, 0.05 m) in Et2O (100 ml) is heated at reflux with stirring. After 15 hours, the 2-chloro-3-aminopyridine HCl is filtered off and the solution concentrated to dryness to yield 2-chloro-3-thionylaminopyridine (1).

Workup

  1. temperatureat reflux
  2. filtrationthe 2-chloro-3-aminopyridine HCl is filtered off
  3. concentrationthe solution concentrated to dryness

Sources & evidence

ORD record
ord-946f188d31b94910bf3d53b3e180c404
Source dataset
uspto-grants-1979_03
Patent number
US04144343

Reaction notes

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