Phosgene → HCID 12445647, compound

HRID 614339Notes

Reaction equation

HRID 614339 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[NH:4][C:5]1[C:10]([NH2:11])=[CH:9][C:8]([N+:12]([O-:14])=[O:13])=[CH:7][N:6]=1.[C:19](Cl)(Cl)=[O:20]>C1C=CC=CC=1>[F:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[N:4]1[C:5]2=[N:6][CH:7]=[C:8]([N+:12]([O-:14])=[O:13])[CH:9]=[C:10]2[NH:11][C:19]1=[O:20]

Participants

4

Reactant 2

HCID 6371PhosgeneHCID 12445400HCID 12445400, compound

Product 1

HCID 12445647HCID 12445647, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The product from Step B (750 mg.) is dissolved in 150 ml. of benzene and treated with phosgene until reaction is complete. After standing 2 hours, the precipitate is collected and recrystallized from ethanol to give 1,3-dihydro-3-(2-fluorophenyl)-6-nitroimidazo[4,5-b]pyridin-2-one, m.p. 234°-236° C.

Workup

  1. customthe precipitate is collected
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-b037aefe2a8644e3bc43f48c5d26c6de
Source dataset
uspto-grants-1979_03
Patent number
US04144341

Reaction notes

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