HCID 12445616, compound → 1,3-Dihydro-3-(3,4-methylenedioxyphenyl)-1-(2-hydroxy-2-phenylethyl)imidazo[4,5-b]pyridin-2-one

HRID 614344Notes

Reaction equation

HRID 614344 reaction equation
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([N:10]3[C:14]4=[N:15][CH:16]=[CH:17][CH:18]=[C:13]4[N:12]([CH2:19][C:20]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)=[O:21])[C:11]3=[O:28])=[CH:4][C:3]=2[O:2]1>[Pt]=O.CO>[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([N:10]3[C:14]4=[N:15][CH:16]=[CH:17][CH:18]=[C:13]4[N:12]([CH2:19][CH:20]([OH:21])[C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)[C:11]3=[O:28])=[CH:4][C:3]=2[O:2]1

Participants

4

Reactant 1

HCID 12445616HCID 12445616, compound

Product 1

HCID 213293081,3-Dihydro-3-(3,4-methylenedioxyphenyl)-1-(2-hydroxy-2-phenylethyl)imidazo[4,5-b]pyridin-2-one

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

A mixture of 431 mg. of 1,3-dihydro-3-(3,4-methylenedioxyphenyl)-1-phenacylimidazo[4,5-b]pyridin-2-one in 30 ml. of methanol was hydrogenated over 25 mg. of platinum oxide. The catalyst was removed by filtration and the filtrate was evaporated to dryness to give a glass which could not be crystallized.

Workup

  1. additionA mixture of 431 mg
  2. customThe catalyst was removed by filtration
  3. customthe filtrate was evaporated to dryness
  4. customto give a glass which could not
  5. custombe crystallized

Sources & evidence

ORD record
ord-9c56b2e8387b4b368552c9aeaa19c4f8
Source dataset
uspto-grants-1979_03
Patent number
US04144341

Reaction notes

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