反应详情

A mixture of 17 parts of 4-(1-piperazinyl)phenol dihydrobromide, 7 parts of ethyl carbonochloridate, 21 parts of potassium carbonate and 250 parts of 1,4-dioxane is stirred and refluxed for 48 hours. The reaction mixture is filtered, while hot and the filtrate is evaporated. The solid residue is dissolved in a diluted hydrochloric acid solution. The solution is alkalized with ammonium hydroxide. The product is filtered off and dried, yielding 3.5 parts of ethyl 4-(4-hydroxyphenyl)-1-piperazinecarboxylate; mp. 168.8° C.

1. temperaturerefluxed for 48 hours
2. filtrationThe reaction mixture is filtered
3. customwhile hot and the filtrate is evaporated
4. dissolutionThe solid residue is dissolved in a diluted hydrochloric acid solution
5. filtrationThe product is filtered off
6. customdried