1,2-Ethanediamine, N1,N1-bis(1-methylethyl)- → Pramiracetam

HRID 614468Notes

Reaction equation

HRID 614468 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([O:10]CC)=O.[CH:13]([N:16]([CH:20]([CH3:22])[CH3:21])[CH2:17][CH2:18][NH2:19])([CH3:15])[CH3:14]>>[CH3:14][CH:13]([N:16]([CH:20]([CH3:22])[CH3:21])[CH2:17][CH2:18][NH:19][C:8](=[O:10])[CH2:7][N:3]1[CH2:4][CH2:5][CH2:6][C:2]1=[O:1])[CH3:15]

Participants

3

Reactant 2

HCID 84591,2-Ethanediamine, N1,N1-bis(1-methylethyl)-HCID 109094Ethyl 2-oxopyrrolidine-1-acetate

Product 1

HCID 51712Pramiracetam

Procedure

From 17.1 g. of ethyl 2-oxo-1-pyrrolidineacetate and 21 g. of 2-(diisopropylamino)ethylamine [J.A.C.S. 78, 486 (1956)], following the procedure of Example 1, there is obtained N-[2-[bis(1-methylethyl)amino]ethyl]-2-oxo-1-pyrrolidineacetamide; b.p. 164° C./0.15 mm.

Sources & evidence

ORD record
ord-6e8481b23a054f1b87540270340adc82
Source dataset
uspto-grants-1979_03
Patent number
US04145347

Reaction notes

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