cis-3-[2,6-Dimethylpiperidinyl]propylamine → cis-(+/-)-N-[3-(2,6-dimethyl-1-piperidinyl)propyl]-alpha-methyl-2-oxo-1-pyrrolidineacetamide

HRID 614485Notes

Reaction equation

HRID 614485 reaction equation
[CH3:1][CH:2]([N:8]1[CH2:12][CH2:11][CH2:10][C:9]1=[O:13])[C:3]([O:5]CC)=O.[CH3:14][C@H:15]1[CH2:20][CH2:19][CH2:18][C@@H:17]([CH3:21])[N:16]1[CH2:22][CH2:23][CH2:24][NH2:25]>>[CH3:14][C@H:15]1[CH2:20][CH2:19][CH2:18][C@@H:17]([CH3:21])[N:16]1[CH2:22][CH2:23][CH2:24][NH:25][C:3](=[O:5])[CH:2]([CH3:1])[N:8]1[CH2:12][CH2:11][CH2:10][C:9]1=[O:13]

Participants

3

Reactant 2

HCID 7176132cis-3-[2,6-Dimethylpiperidinyl]propylamineHCID 15044021Ethyl alpha-methyl-2-oxo-1-pyrrolidineacetate

Product 1

HCID 22807215cis-(+/-)-N-[3-(2,6-dimethyl-1-piperidinyl)propyl]-alpha-methyl-2-oxo-1-pyrrolidineacetamide

Procedure

From 9.25 g. of ethyl α-methyl-2-oxo-1-pyrrolidineacetate and 10.5 g. of cis-3-(2,6-dimethyl-1-piperidinyl)propylamine, following the procedure of Example 21, there is obtained cis-(±)-N-[3-(2,6-dimethyl-1-piperidinyl)propyl]-α-methyl-2-oxo-1-pyrrolidineacetamide; b.p. 165°-170° C./0.1 mm.

Sources & evidence

ORD record
ord-80f1fc880dbf4760a606967af394d539
Source dataset
uspto-grants-1979_03
Patent number
US04145347

Reaction notes

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