2-Thiopheneacetyl chloride → HCID 131711462, compound

HRID 614645Notes

Reaction equation

HRID 614645 reaction equation
N[CH:2]1[C:17](=[O:18])[N:4]2[C:5]([C:14]([OH:16])=[O:15])=[C:6]([CH2:9][O:10][C:11](=[O:13])[NH2:12])[CH2:7][S:8][C@H:3]12.S1C=CC=C1CC(Cl)=O.[S:28]1[CH:32]=[CH:31][CH:30]=[C:29]1[CH2:33][C:34]([NH:36]C1C(=O)N2C(C(O)=O)=C(COC(=O)N)CS[C@H]12)=[O:35]>>[S:28]1[CH:32]=[CH:31][CH:30]=[C:29]1[CH2:33][C:34]([NH:36][CH:7]1[C:6]([CH2:9][O:10][C:11](=[O:13])[NH2:12])=[C:5]([C:14]([OH:16])=[O:15])[N:4]2[C:17](=[O:18])[CH2:2][C@H:3]2[S:8]1)=[O:35]

Participants

4

Reactant 3

HCID 1623622-Thiopheneacetyl chlorideHCID 127847593-Carbamoyloxymethyl-7-amino-3-cephem-4-carboxylic acidHCID 70567479HCID 70567479, compound

Product 1

HCID 131711462HCID 131711462, compound

Procedure

A third 1 μl portion of the 7-amino-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid-containing solution, prepared as reported in Example 11, was treated as described in Example 11, except that the acyl halide was 2-thiopheneacetyl chloride, and the resulting product was 7-(2-(2-thienyl)acetamido)-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid. It exhibited an RCV value of 0.39.

Workup

  1. customprepared
  2. additionwas treated

Sources & evidence

ORD record
ord-329b4637649d4ddc903830acd528fa1e
Source dataset
uspto-grants-1979_03
Patent number
US04145538

Reaction notes

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