Ethanol → HCID 13021287, compound

HRID 614655Notes

Reaction equation

HRID 614655 reaction equation
[C:1]([O:5][C:6](=[O:33])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:32])[C@H:13]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[NH:14]C(OCC1C=CC=CC=1)=O)([CH3:4])([CH3:3])[CH3:2].C(O)C>O1CCCC1>[C:1]([O:5][C:6](=[O:33])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:32])[C@H:13]([CH2:25][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[NH2:14])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 702EthanolHCID 13021285HCID 13021285, compound

Product 1

HCID 13021287HCID 13021287, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

223 g of N-carbobenzoxy-L-phenylalanyl-L-proline tert.-butyl ester is hydrogenated in analogous manner to step (b), using 2100 ml absolute tetrahydrofuran as solvent instead of ethanol, to give the heading compound as a colourless oil.

Sources & evidence

ORD record
ord-16ed630250444fc58edbd1ade2ef2a47
Source dataset
uspto-grants-1979_03
Patent number
US04145549

Reaction notes

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