反应详情

30.5 g (0.27 mol) of chlorobenzene and 36 g (0.27 mol) of aluminium chloride are introduced into a 250 cm3 flask and 25 g (0.135 mol) of m-nitrobenzoyl chloride dissolved in 15 cm3 of chlorobenzene are added dropwise. The mixture is heated for 5 hours at between 50° and 60° C. and is then allowed to cool and is hydrolysed with 500 g of ice + 20 cm3 of concentrated HCl (d = 1.18); the batch is extracted with ether and the extract is washed with aqueous sodium hydroxide solution (strength 30 g/l) and then with water; the ether phase is dried, decolorised and then evaporated in vacuo; 26 g of the expected ketone are obtained. Melting point 97° C.

1. additionare added dropwise
2. temperatureThe mixture is heated for 5 hours at between 50° and 60° C.
3. temperatureto cool
4. extractionthe batch is extracted with ether
5. washthe extract is washed with aqueous sodium hydroxide solution (strength 30 g/l)
6. dry with materialthe ether phase is dried
7. customevaporated in vacuo