Hydrogen Bromide → HCID 70573577, compound

HRID 614742Notes

Reaction equation

HRID 614742 reaction equation
[C:1]([CH2:3][O:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=3)[CH2:10][C:11]([CH3:16])([CH3:15])[O:12]2)=[CH:7][CH:6]=1)#[N:2].[BrH:27]>[Pd].C(O)C>[BrH:27].[NH2:2][CH2:1][CH2:3][O:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:24])[F:25])[CH:18]=3)[CH2:10][C:11]([CH3:15])([CH3:16])[O:12]2)=[CH:7][CH:6]=1

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 20570498HCID 20570498, compound

Product 1

HCID 70573577HCID 70573577, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 7-cyanomethyloxy-2,2-dimethyl-4-(3-trifluoromethylphenyl)chroman (5.4 g) and 10% palladium on charcoal (0.5 g) in ethanol (75 ml) was hydrogenated at atmospheric pressure. The catalyst was removed by filtration and the filtrate evaporated under reduced pressure to give an oil which was treated with ethereal hydrogen bromide to give the title compound (4 g) as a very hygroscopic non-crystalline compound.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated under reduced pressure
  3. customto give an oil which

Sources & evidence

ORD record
ord-94cc96df35d94a52a0f8ee9484d80ee5
Source dataset
uspto-grants-1979_03
Patent number
US04146539

Reaction notes

Loading…