HCID 86736427, compound → HCID 21327117, compound

HRID 614773Notes

Reaction equation

HRID 614773 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH3:12])[CH:11]=1)[N:8]([CH2:13][C:14]([F:17])([F:16])[F:15])[CH:7]=[C:6]([C:18]([O:20]CC)=[O:19])[C:5]2=[O:23]>Cl>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH3:12])[CH:11]=1)[N:8]([CH2:13][C:14]([F:17])([F:16])[F:15])[CH:7]=[C:6]([C:18]([OH:20])=[O:19])[C:5]2=[O:23]

Participants

3

Reactant 1

HCID 86736427HCID 86736427, compound

Product 1

HCID 21327117HCID 21327117, compoundYield 104.7%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 38.0 g of 6-fluoro-1,4-dihydro-8-methyl-4-oxo-1-(2,2,2-trifluoroethyl)-3-quinolinecarboxylic acid, ethyl ester and 800 ml of 6N hydrochloric acid was heated at reflux for 1.5 hours; the reaction mass was cooled, filtered, washed with water, and dried to give 36.4 g of 6-fluoro-1,4-dihydro-8-methyl-4-oxo-1-(2,2,2-trifluoroethyl)-3-quinolinecarboxylic acid, m.p. 221°-223°.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 1.5 hours
  3. temperaturethe reaction mass was cooled
  4. filtrationfiltered
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-2fbc01ad4b1243e79d1fcee361a60c94
Source dataset
uspto-grants-1979_03
Patent number
US04146625

Reaction notes

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