反应详情

To a suspension of 23.0 g. 2,3-diamino-1-[2-hydroxy-3-(4-phenoxymethylpiperidino)-propoxy]-benzene trihydrochloride in 150 ml. water and 8.8 ml. concentrated hydrochloric acid, there is added dropwise at 0° C. a solution of 3.3 g. sodium nitrite in 37 ml. water. After standing overnight, the reaction mixture is filtered and the precipitate is recrystallized from methanol. There are obtained 9.5 g. (47% of theory) 4-[2-hydroxy-3-(4-phenoxymethylpiperidino)-propoxy]-benzotriazole hydrochloride; m.p. 187°-189° C.

1. additionTo a suspension of 23.0 g
2. filtrationthe reaction mixture is filtered
3. customthe precipitate is recrystallized from methanol
4. customThere are obtained 9.5 g