Acetic Anhydride → HCID 21327245, compound

HRID 614838Notes

Reaction equation

HRID 614838 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][C:16](=[O:18])[CH3:17])[C:10]=1[CH2:19][CH2:20][O:21][C:22](=[O:24])[CH3:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:25](OCCC(C)C)=O.C([O-])(=O)C.[Na+].C(OC(=O)C)(=O)C>C1(C)C=CC=CC=1>[C:16]([N:15]1[C:11]2[C:10](=[C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:14]=[CH:13][CH:12]=2)[C:19]([CH2:20][O:21][C:22](=[O:24])[CH3:23])=[N:25]1)(=[O:18])[CH3:17]

Participants

6

Reactant 4

HCID 7918Acetic AnhydrideHCID 8053Isoamyl NitriteHCID 517045Sodium AcetateHCID 21327278HCID 21327278, compound

Product 1

HCID 21327245HCID 21327245, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

This is obtained by nitrosation and subsequent ring closure by treating 2-(2-acetoxyethyl)-3-acetamidophenyl benzyl ether with isoamyl nitrite, sodium acetate and acetic anhydride in toluene at 80° C. It is obtained in the form of colorless crystals; m.p. 99°-100° C.

Workup

  1. customThis is obtained by nitrosation and subsequent ring closure
  2. customIt is obtained in the form of colorless crystals

Sources & evidence

ORD record
ord-ca3f49e8eeb740218775e6f47c2e4b55
Source dataset
uspto-grants-1979_03
Patent number
US04146630

Reaction notes

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