Hydrochloric Acid → HCID 178478883, compound

HRID 614839Notes

Reaction equation

[ClH:1].C([O:5][CH2:6][C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[O:16][CH2:17][CH:18]([OH:34])[CH2:19][N:20]2[CH2:25][CH2:24][CH:23]([CH2:26][O:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:22][CH2:21]2)[NH:9][N:8]=1)(=O)C>>[ClH:1].[ClH:1].[OH:34][CH:18]([CH2:19][N:20]1[CH2:21][CH2:22][CH:23]([CH2:26][O:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:24][CH2:25]1)[CH2:17][O:16][C:14]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:15]=1[C:7]([CH2:6][OH:5])=[N:8][NH:9]2

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 178475924HCID 178475924, compound

Product 1

HCID 178478883HCID 178478883, compoundYield 48%

Procedure

Excess ethanolic hydrochloric acid is allowed to act upon 3-acetoxymethyl-4-[2-hydroxy-3-(4-phenoxymethylpiperidino)-propoxy]-indazole, followed by precipitation with diethyl ether and recrystallization of the precipitate from ethanol. There is obtained, in a yield of 48% of theory, 4-[2-hydroxy-3-(4-phenoxymethylpiperidino)-propoxy]-3-hydroxymethylindazole dihydrochloride in the form of pale yellow crystals; m.p. 183° C. (decomp.).

Workup

customfollowed by precipitation with diethyl ether and recrystallization of the precipitate from ethanol

Sources & evidence

ORD record: ord-8715d2d64b5445348db31f8c1a02fa54
Source dataset: uspto-grants-1979_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04146630

Reaction notes

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