m-Chloroperbenzoic acid → HCID 54281552, compound

HRID 614846Notes

Reaction equation

HRID 614846 reaction equation
[CH3:1][O:2][C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([S:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)=[CH:10][N:9]2[CH:21]=1)=[O:4].ClC1C=CC=C(C(OO)=[O:30])C=1>C(Cl)Cl>[CH3:1][O:2][C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([S:14]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)=[O:30])=[CH:10][N:9]2[CH:21]=1)=[O:4]

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 53984327HCID 53984327, compound

Product 1

HCID 54281552HCID 54281552, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 0.300 g. (1 mmole) of 2-methoxycarbonylamino-6-(pyridylthio)-imidazo [1,2-a] pyridine in 50 ml. of methylene chloride is added 0.189 g. (1.1 mmoles) of m-chloroperbenzoic acid. The reaction is stirred at room temperature overnight, and the resultant solution is washed 3 times with saturated sodium bicarbonate solution. The methylene chloride layer is dried and evaporated to dryness in vacuo affording 2-methoxycarbonylamino-6-(2-pyridylsulfinyl) imidazo [1,2-a] pyridine, m.p. 231°-235° C.

Workup

  1. washthe resultant solution is washed 3 times with saturated sodium bicarbonate solution
  2. dry with materialThe methylene chloride layer is dried
  3. customevaporated to dryness in vacuo

Sources & evidence

ORD record
ord-e04c067d4bef48ae927b0ad3a2f9adf6
Source dataset
uspto-grants-1979_03
Patent number
US04146642

Reaction notes

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