Ethyl formate → HCID 21327419, compound

HRID 614873Notes

Reaction equation

HRID 614873 reaction equation
[NH:1]([C:5]1[CH:6]=[C:7]([CH2:11][CH:12]([NH2:14])[CH3:13])[CH:8]=[CH:9][CH:10]=1)[C:2]([NH2:4])=[O:3].[CH:15](OCC)=[O:16]>>[NH:1]([C:5]1[CH:6]=[C:7]([CH2:11][CH:12]([NH:14][CH:15]=[O:16])[CH3:13])[CH:8]=[CH:9][CH:10]=1)[C:2]([NH2:4])=[O:3]

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 21327414N-[3-(2-Aminopropyl)phenyl]urea

Product 1

HCID 21327419HCID 21327419, compound

Procedure

A mixture consisting of 4.8 gm of 1-(3'-ureido-phenyl)-2-amino-propane and 5 ml of ethyl formate was refluxed for five hours. Thereafter, the reaction solution was evaporated, and the residue was purified by chromatography on a silicagel column, using methanol/chloroform (2:8) as the flow agent. The eluate was evaporated, and the residue was recrystallized from ethanol and ether, yielding the compound of the formula ##STR23## which had a melting point of 133°-136° C.

Workup

  1. temperaturewas refluxed for five hours
  2. customThereafter, the reaction solution was evaporated
  3. customthe residue was purified by chromatography on a silicagel column
  4. customThe eluate was evaporated
  5. customthe residue was recrystallized from ethanol and ether
  6. customyielding the compound of the formula ##STR23## which

Sources & evidence

ORD record
ord-bcb949f35d73413badcc1d49475e3c22
Source dataset
uspto-grants-1979_03
Patent number
US04146645

Reaction notes

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