2-Aminopyrimidine → 64204-40-6

HRID 614881Notes

Reaction equation

HRID 614881 reaction equation
C(=O)(O)[O-].[Na+].[NH2:6][C:7]1[N:12]=[CH:11][CH:10]=[CH:9][N:8]=1.[Cl:13][C:14]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:15]=1[CH2:16]Cl>O>[ClH:13].[Cl:13][C:14]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:15]=1[CH2:16][NH:6][C:7]1[N:12]=[CH:11][CH:10]=[CH:9][N:8]=1

Participants

5

Reactant 3

HCID 79782-AminopyrimidineHCID 748322,6-Dichlorobenzyl chlorideHCID 516892Sodium Bicarbonate

Product 1

HCID 2132745264204-40-6

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10.5 g (0.125 mol) of sodium bicarbonate in 100 ml of distilled water are introduced into a solution of 38 g (0.4 mol) of 2-amino-pyrimidine at 90°-95° C., after which 19.55 g (0.1 mol) of 2,6-dichlorobenzyl chloride are introduced in 1 hour, and the mixture is then left at 90°-95° C. for 4 hours. It is cooled and the insoluble matter is filtered off and washed copiously with distilled water. This insoluble matter is recrystallised from ethyl acetate. Thereafter it is dissolved in hot ethyl acetate and the hydrochloride is precipitated by means of a solution of hydrogen chloride in ether.

Workup

  1. temperatureIt is cooled
  2. filtrationthe insoluble matter is filtered off
  3. washwashed copiously with distilled water
  4. customThis insoluble matter is recrystallised from ethyl acetate
  5. dissolutionThereafter it is dissolved in hot ethyl acetate
  6. customthe hydrochloride is precipitated by means of a solution of hydrogen chloride in ether

Sources & evidence

ORD record
ord-f9ed6322012e42c684abb63ad655855f
Source dataset
uspto-grants-1979_03
Patent number
US04146647

Reaction notes

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