HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetamide → 2-Cyano-3-(morpholin-4-yl)prop-2-enamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Cyano-3-(morpholin-4-yl)prop-2-enamide | HCID 91341 | — |
Reaction Steps
A stirred mixture of cyanoacetamide (63 g.), triethylorthoformate (134 g.), morpholine (82.5 g.) and acetonitrile (37.5 ml.) was heated under reflux for 4 hours. The initial reflux temperature was 117° C. and the final reflux temperature was 82° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04146713 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-00db794a5ef9409db62f956a5fa94cad |
| Source note | uspto-grants-1979_03 |