Cyanoacetamide → 2-Cyano-3-(morpholin-4-yl)prop-2-enamide

HRID 614889Notes

Reaction equation

HRID 614889 reaction equation
[C:1]([CH2:3][C:4]([NH2:6])=[O:5])#[N:2].[CH2:7](OC(OCC)OCC)C.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>C(#N)C>[O:20]1[CH2:21][CH2:22][N:17]([CH:7]=[C:3]([C:1]#[N:2])[C:4]([NH2:6])=[O:5])[CH2:18][CH2:19]1

Participants

5

Reactant 3

HCID 7898CyanoacetamideHCID 8083MorpholineHCID 31214Ethyl orthoformate

Product 1

HCID 913412-Cyano-3-(morpholin-4-yl)prop-2-enamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A stirred mixture of cyanoacetamide (63 g.), triethylorthoformate (134 g.), morpholine (82.5 g.) and acetonitrile (37.5 ml.) was heated under reflux for 4 hours. The initial reflux temperature was 117° C. and the final reflux temperature was 82° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 4 hours
  3. temperatureThe initial reflux temperature
  4. customwas 117° C.
  5. temperaturethe final reflux temperature
  6. customwas 82° C.

Sources & evidence

ORD record
ord-00db794a5ef9409db62f956a5fa94cad
Source dataset
uspto-grants-1979_03
Patent number
US04146713

Reaction notes

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