Potassium Nitrate → HCID 21327506, compound

HRID 614917Notes

Reaction equation

HRID 614917 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:10][C:9]1=[O:24].[N+:25]([O-])([O-:27])=[O:26].[K+]>S(=O)(=O)(O)O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][N:8]1[C:17]2[C:12](=[CH:13][C:14]([N+:25]([O-:27])=[O:26])=[CH:15][CH:16]=2)[C:11]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:10][C:9]1=[O:24]

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 21327528HCID 21327528, compound

Product 1

HCID 21327506HCID 21327506, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent2×

Procedure

To a solution of 3.13 g of 1-(2-pyridylmethyl)-4-phenyl-2(1H)-quinazolinone in 10 ml of concentrated sulfuric acid was added dropwise a solution of 1 g of potassium nitrate in 3 ml of concentrated sulfuric acid with cooling by an ice bath. The resulting mixture was stirred at room temperature for 3 hours and then poured onto cracked ice. The precipitate was collected by filtration, washed successively with water and ammonia water and dried to give 1-(2-pyridylmethyl)-4-phenyl-6-nitro-2(1H)-quinazolinone. Recrystallization from chloroform gave colorless fine crystals, m.p. 175°-176° C.

Workup

  1. temperaturewith cooling by an ice bath
  2. additionpoured
  3. filtrationThe precipitate was collected by filtration
  4. washwashed successively with water and ammonia water
  5. customdried

Sources & evidence

ORD record
ord-ae6b36ebfc4e43e6b5f0e6f96630ffc2
Source dataset
uspto-grants-1979_03
Patent number
US04146717

Reaction notes

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