反应详情

A mixture of 9-(2-hydroxyethoxymethyl)guanine (4.6 g), dry dimethylformamide (46 ml), acetic anhydride (16 ml) and dry pyridine (24 ml) was stirred at room temperature overnight. The resulting white solid was removed by filtration and dissolved in warm dimethylformamide (100 ml), pyridine (10 ml) and acetic anhydride (8 ml) added and the mixture stirred for 18 hr. The white solid formed was removed by filtration, washed with ethyl acetate and recrystallized from dimethylformamide to give 9-(2-acetyloxyethoxymethyl)guanine (3.3 g), m.p. 240°-241° C.

1. customThe resulting white solid was removed by filtration
2. dissolutiondissolved in warm dimethylformamide (100 ml)
3. additionpyridine (10 ml) and acetic anhydride (8 ml) added
4. stirringthe mixture stirred for 18 hr
5. customThe white solid formed
6. customwas removed by filtration
7. washwashed with ethyl acetate
8. customrecrystallized from dimethylformamide