Ammonia → 3,5-Dimethyl-1-phenyl-pyrazol-4-acetamide
Reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]1[C:6]([CH3:17])=[N:7][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:9]=1[CH3:10].[NH3:19]>CO>[CH3:17][C:6]1[C:5]([CH2:4][C:3]([NH2:19])=[O:2])=[C:9]([CH3:10])[N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 160 °C
Procedure
6 grams 3,5-dimethyl-1-phenyl-pyrazol-4-acetic acid-methyl-ester and 80 milliliters ammonia solution in methanol were mixed and the mixture heated in an autoclave to 160° C. for 6 hours. The reaction mixture was evaporated to dryness. 4.6 grams 3,5-dimethyl-1-phenyl-pyrazol-4-acetamide, melting at 160°-170° C., were obtained, representing a yield of 81%.
Workup
- customThe reaction mixture was evaporated to dryness
Sources & evidence
- ORD record
- ord-72033472cfb74e11872e0efa67fa6e60
- Source dataset
- uspto-grants-1979_03
- Patent number
- US04146721
Reaction notes
Loading…