HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 615032Generated: October 31, 2026
Ammonia → 3,5-Dimethyl-1-phenyl-pyrazol-4-acetamide
https://huagongshe.com/reaction/615032
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3,5-Dimethyl-1-phenyl-pyrazol-4-acetic acid methyl ester | HCID 20542682 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3,5-Dimethyl-1-phenyl-pyrazol-4-acetamide | HCID 20542721 | 81% |
Reaction Steps
6 grams 3,5-dimethyl-1-phenyl-pyrazol-4-acetic acid-methyl-ester and 80 milliliters ammonia solution in methanol were mixed and the mixture heated in an autoclave to 160° C. for 6 hours. The reaction mixture was evaporated to dryness. 4.6 grams 3,5-dimethyl-1-phenyl-pyrazol-4-acetamide, melting at 160°-170° C., were obtained, representing a yield of 81%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04146721 |
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| Source dataset | uspto-grants-1979_03 |
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| ORD ID | ord-72033472cfb74e11872e0efa67fa6e60 |
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| Source note | uspto-grants-1979_03 |
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