p-Toluenesulfonic acid → 2,3,4,5,6-Pentahydroxyhexyl 4-(n-hexadecylamino)benzoate

Participants

Reaction Steps

In the manner described in Example 7, 3.62 g. of 4-(n-hexadecylamino)benzoic acid, 1.82 g. of mannitol, and 2.06 g. of p-toluene sulfonic acid are reacted to yield a mixture of mono- and bis-acylated products. Pure 2,3,4,5,6-pentahydroxyhexyl 4-(n-hexadecylamino)benzoate is separated from the mixture by adsorption chromatography using silica gel as the adsorbant.

Provenance & Evidence