HRID615056

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

结构：OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

HCID6251

未命名化合物

HCID47263

Cetaben

C23H39NO2

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCCNc1ccc(C(=O)OCC(O)C(O)C(O)C(O)CO)cc1

HCID21326956

未命名化合物

PROCEDURE

实验过程

In the manner described in Example 7, 3.62 g. of 4-(n-hexadecylamino)benzoic acid, 1.82 g. of mannitol, and 2.06 g. of p-toluene sulfonic acid are reacted to yield a mixture of mono- and bis-acylated products. Pure 2,3,4,5,6-pentahydroxyhexyl 4-(n-hexadecylamino)benzoate is separated from the mixture by adsorption chromatography using silica gel as the adsorbant.

WORKUP

后处理

customto yield
additiona mixture of mono- and bis-acylated products
customPure 2,3,4,5,6-pentahydroxyhexyl 4-(n-hexadecylamino)benzoate is separated from the mixture by adsorption chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ffccab57ebcf4005be5a4b50ce52cbec
来源数据集: uspto-grants-1979_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04146546
来源说明: uspto-grants-1979_03

反应 SMILES

[CH2:1]([NH:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[CH2:27](O)[C@H:28]([C@H:30]([C@@H:32]([C@@H:34]([CH2:36][OH:37])[OH:35])[OH:33])[OH:31])[OH:29].C1(C)C=CC(S(O)(=O)=O)=CC=1>>[CH2:1]([NH:17][C:18]1[CH:19]=[CH:20][C:21]([C:22]([O:24][CH2:27][CH:28]([OH:29])[CH:30]([OH:31])[CH:32]([OH:33])[CH:34]([OH:35])[CH2:36][OH:37])=[O:23])=[CH:25][CH:26]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]