3-Chloro-1,2-propanediol → HCID 21326945, compound

HRID 615058Notes

Reaction equation

HRID 615058 reaction equation
[CH2:1]([NH:9][C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[H-].[Na+].Cl[CH2:22][CH:23]([OH:26])[CH2:24][OH:25]>CN(C)P(N(C)C)(N(C)C)=O>[CH2:1]([NH:9][C:10]1[CH:11]=[CH:12][C:13]([C:14]([O:16][CH2:22][CH:23]([OH:26])[CH2:24][OH:25])=[O:15])=[CH:17][CH:18]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

5

Reactant 3

HCID 72903-Chloro-1,2-propanediolHCID 24758Sodium hydrideHCID 13105493HCID 13105493, compound

Product 1

HCID 21326945HCID 21326945, compound

Reagents, catalysts & solvents 1

HCID 12679HexamethylphosphoramideSolvent

Procedure

A solution of 4-(n-octylamino)benzoic acid (4.97 g.) in 25 ml. of hexamethylphosphoramide is treated with sodium hydride and then 1-chloro-2,3-propanediol in the manner described in Example 2 to produce white crystals of 2,3-dihydroxypropyl 4-(n-octylamino)benzoate.

Sources & evidence

ORD record
ord-de35118001e2431389c12ea342c059d4
Source dataset
uspto-grants-1979_03
Patent number
US04146546

Reaction notes

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