Water → HCID 20429147, compound

Participants

Reaction Steps

To a solution of 1.83 g of 3,5-dichloro-4H-1,2,6-thiadiazin-4-one in 50 ml CH2Cl2 is added a solution of 50 ml of water, 1.54 g of 3,5-dimethoxyphenol, 5 ml of 2N aqueous sodium hydroxide solution and 0.1 g of tetra-n-butylammonium chloride. The two phase mixture is stirred at room temperature for 3 hours. Then the layers are separated, and the organic layer is dried over magnesium sulfate and concentrated. The residue is recrystallized from alcohol to yield white crystals, mp 121°-124°.

Provenance & Evidence