3,5-Dichloro-4H-1,2,6-thiadiazin-4-one → 3-Chloro-5-methoxy-4H-1,2,6-thiadiazin-4-one

Participants

Reaction Steps

A solution of 3.66 g of 3,5-dichloro-4H-1,2,6-thiadiazin-4-one in 30 ml of methanol is kept at 0°-5° C. and stirred while a solution of 2.40 g of sodium methoxide in 30 ml of methanol is added dropwise to it. The reaction mixture is stirred at room temperature 2 hours longer, then mixed with 200 ml of ice water. The precipitate is collected, washed with water, dried, and recrystallized from hexane to yield pale yellow needles, mp 159°-161°.

Provenance & Evidence