Methyl iodide → HCID 70486577, compound

Participants

Reaction Steps

The 1-alkyl-3-amino-5-pyridinyl-1,2,4-triazole may be readily prepared from the corresponding 3-amino-5-pyridinyl-1,2,4-triazole under alkylating conditions. For instance, reaction of 3-amino-5-pyridinyl-1,2,4-triazole with sodium hydride followed by addition of methyl iodide yields the 1-methyl-3-amino-5-pyridinyl-1,2,4-triazole plus other isomers. Separation of the desired product may be readily accomplished by chromatography, distillation and the like.

Provenance & Evidence