Methyl iodide → HCID 70486577, compound

HRID 615151Notes

Reaction equation

HRID 615151 reaction equation
[NH2:1][C:2]1[N:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[NH:4][N:3]=1.[H-].[Na+].[CH3:15]I>>[CH3:15][N:4]1[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)=[N:6][C:2]([NH2:1])=[N:3]1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 120117925-(pyridin-2-yl)-4H-1,2,4-triazol-3-amine2×

Product 1

HCID 70486577HCID 70486577, compound

Procedure

The 1-alkyl-3-amino-5-pyridinyl-1,2,4-triazole may be readily prepared from the corresponding 3-amino-5-pyridinyl-1,2,4-triazole under alkylating conditions. For instance, reaction of 3-amino-5-pyridinyl-1,2,4-triazole with sodium hydride followed by addition of methyl iodide yields the 1-methyl-3-amino-5-pyridinyl-1,2,4-triazole plus other isomers. Separation of the desired product may be readily accomplished by chromatography, distillation and the like.

Sources & evidence

ORD record
ord-05658251918845b0bcd47a4821df0735
Source dataset
uspto-grants-1985_02
Patent number
US04497814

Reaction notes

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