Hydrochloric Acid → HCID 70491112, compound

HRID 615162Notes

Reaction equation

HRID 615162 reaction equation
[ClH:1].C([NH:5][C:6]1[CH:7]=[C:8]([C:12]2[N:13]=[C:14]3[N:18]([CH:19]=2)[C:17]2[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=2[S:15]3)[CH:9]=[CH:10][CH:11]=1)(=[O:4])C>CO>[OH2:4].[ClH:1].[ClH:1].[NH2:5][C:6]1[CH:7]=[C:8]([C:12]2[N:13]=[C:14]3[N:18]([CH:19]=2)[C:17]2[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=2[S:15]3)[CH:9]=[CH:10][CH:11]=1.[NH2:5][C:6]1[CH:7]=[C:8]([C:12]2[N:13]=[C:14]3[N:18]([CH:19]=2)[C:17]2[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=2[S:15]3)[CH:9]=[CH:10][CH:11]=1.[ClH:1].[ClH:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12926134N-(3-Imidazo[2,1-b]benzothiazol-2-ylphenyl)acetamide

Product 1

HCID 70491112HCID 70491112, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 30 ml of a 2 normal hydrochloric acid solution and 20 ml of methanol was added 4 g of 2-(m-acetamidophenyl)imidazo[2,1-b]benzothiazole and the mixture was refluxed for 2 hours. The reaction mixture was concentrated under reduced pressure to form solid materials, which were recrystallized from ethanol to provide 4.2 g of 2-(m-aminophenyl)imidazo[2,1-b]benzothiazole di-hydrochloride hemihydrate.

Workup

  1. temperaturethe mixture was refluxed for 2 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customto form solid materials, which
  4. customwere recrystallized from ethanol

Sources & evidence

ORD record
ord-165028bf75674dbeb08e781d10061c4d
Source dataset
uspto-grants-1985_02
Patent number
US04497817

Reaction notes

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