Hydrochloric Acid → HCID 70480527, compound

HRID 615198Notes

Reaction equation

[C:1]([O:4][C@@H:5]1[C@@H:22]([OH:23])[CH2:21][C@@:20]2([CH3:24])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:19]2[C@H:18]([NH:25][CH2:26][CH2:27][CH:28]([CH3:30])[CH3:29])[CH2:17][C@@:15]2([CH3:16])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:31]([O:33][CH3:34])=[O:32])[CH2:6]1)(=[O:3])[CH3:2].O.[ClH:36]>>[ClH:36].[C:1]([O:4][C@@H:5]1[C@@H:22]([OH:23])[CH2:21][C@@:20]2([CH3:24])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:19]2[C@H:18]([NH:25][CH2:26][CH2:27][CH:28]([CH3:30])[CH3:29])[CH2:17][C@@:15]2([CH3:16])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:31]([O:33][CH3:34])=[O:32])[CH2:6]1)(=[O:3])[CH3:2]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 962Water

HCID 70480016HCID 70480016, compound

Product 1

HCID 70480527HCID 70480527, compoundYield 0.9%

Procedure

Methyl 3α-acetoxy-2β-hydroxy-11α-(3-methylbutylamino)-5α-androstane-17β-carboxylate (90 mg) was dissolved in 0.0987M HCl solution (1.91 ml) as far as possible. The mixture was made up to 9 g with water and filtered. The residue was collected, dried and weighed (9 mg). This gave a 0.9% solution with respect to free base, pH 2.45.

Workup

filtrationfiltered
customThe residue was collected
customdried

Sources & evidence

ORD record: ord-f984838491a744aba7df4ea990ccd033
Source dataset: uspto-grants-1985_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04497805

Reaction notes

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