Hydrochloric Acid → HCID 70479024, compound

HRID 615199Notes

Reaction equation

[OH:1][C@H:2]1[CH2:19][C@@:18]2([CH3:20])[C@@H:5]([CH2:6][CH2:7][C@@H:8]3[C@@H:17]2[C@H:16]([NH:21][CH2:22][CH2:23][CH:24]([CH3:26])[CH3:25])[CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH2:11][C@@H:12]2[C:27]([O:29][CH2:30][CH2:31][CH3:32])=[O:28])[CH2:4][C@@H:3]1[OH:33].O.[ClH:35]>>[ClH:35].[OH:1][C@H:2]1[CH2:19][C@@:18]2([CH3:20])[C@@H:5]([CH2:6][CH2:7][C@@H:8]3[C@@H:17]2[C@H:16]([NH:21][CH2:22][CH2:23][CH:24]([CH3:26])[CH3:25])[CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH2:11][C@@H:12]2[C:27]([O:29][CH2:30][CH2:31][CH3:32])=[O:28])[CH2:4][C@@H:3]1[OH:33]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 962Water

HCID 70479025HCID 70479025, compound

Product 1

HCID 70479024HCID 70479024, compoundYield 0.5%

Procedure

Propyl 2β,3α-dihydroxy-11α-(3-methylbutylamino)-5α-androstane-17β-carboxylate (40 mg) was dissolved in 0.0987M HCl solution (0.88 ml), made up to 8 g with water and filtered. This gave a 0.5% solution with respect to free base, pH 3.8.

Workup

filtrationfiltered

Sources & evidence

ORD record: ord-eece50ae60c8400187666d0094cc6963
Source dataset: uspto-grants-1985_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04497805

Reaction notes

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