Hydroxyamine hydrochloride → HCID 136399309, compound

Participants

Reaction Steps

To a 20.0 g (0.0995 mole) amount of 1-[5-methyl-2-(3-pyridinyl)-1H-imidazol-4-yl]ethanone (prepared as described in Example 1) dissolved in 500 ml of boiling water were added 15.0 g (0.183 mole) of sodium acetate and 10.0 g (0.144 mole) of hydroxylamine hydrochloride. The mixture was stirred and heated for 4 hours, then cooled to room temperature. The resulting precipitate was collected by filtration and when dried at 140°-160° C. for 24 hours gave 20.3 g of the desired product as a white solid, mp 215°-216° C.

Provenance & Evidence