Hydroxyamine hydrochloride → HCID 136399309, compound

HRID 615319Notes

Reaction equation

HRID 615319 reaction equation
[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:4][C:3]=1[C:13](=O)[CH3:14].C([O-])(=O)C.[Na+].Cl.[NH2:22][OH:23]>O>[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:4][C:3]=1[C:13](=[N:22][OH:23])[CH3:14]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 13387922HCID 13387922, compound

Product 1

HCID 136399309HCID 136399309, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a 20.0 g (0.0995 mole) amount of 1-[5-methyl-2-(3-pyridinyl)-1H-imidazol-4-yl]ethanone (prepared as described in Example 1) dissolved in 500 ml of boiling water were added 15.0 g (0.183 mole) of sodium acetate and 10.0 g (0.144 mole) of hydroxylamine hydrochloride. The mixture was stirred and heated for 4 hours, then cooled to room temperature. The resulting precipitate was collected by filtration and when dried at 140°-160° C. for 24 hours gave 20.3 g of the desired product as a white solid, mp 215°-216° C.

Workup

  1. temperatureheated for 4 hours
  2. filtrationThe resulting precipitate was collected by filtration and when
  3. customdried at 140°-160° C. for 24 hours

Sources & evidence

ORD record
ord-00ceb5226ab74dc5aa6f55d87dd491c0
Source dataset
uspto-grants-1985_02
Patent number
US04499097

Reaction notes

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