Methyl iodide → HCID 13387945, compound

HRID 615322Notes

Reaction equation

HRID 615322 reaction equation
[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:4][C:3]=1[C:13](=[O:15])[CH3:14].[CH3:16][I:17]>CC(C)=O>[I-:17].[C:13]([C:3]1[N:4]=[C:5]([C:7]2[CH:8]=[N+:9]([CH3:16])[CH:10]=[CH:11][CH:12]=2)[NH:6][C:2]=1[CH3:1])(=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 13387922HCID 13387922, compound

Product 1

HCID 13387945HCID 13387945, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A 3.0 g (0.015 mole) amount of 1-[5-methyl-2-(3-pyridinyl)-1H-imidazol-4-yl]ethanone in 300 ml of acetone was treated with 3.0 ml of methyl iodide. The reaction mixture was allowed to stand at room temperature for 24 hours. The precipitate formed was collected by filtration and was washed with 50 ml each of acetone and ether then was dried in vacuo at 60° C. to yield 1.9 g of the desired product as a yellow solid, mp 258°-260° C. (dec.).

Workup

  1. customThe precipitate formed
  2. filtrationwas collected by filtration
  3. washwas washed with 50 ml each of acetone and ether
  4. customthen was dried in vacuo at 60° C.

Sources & evidence

ORD record
ord-c5458b3ccb18422984ed4aae04e43507
Source dataset
uspto-grants-1985_02
Patent number
US04499097

Reaction notes

Loading…