反应详情

To a 1.0 g (0.005 mole) amount of 1-[5-methyl-2-(4-pyridinyl)-1H-imidazol-4-yl]ethanone (prepared as described in Example 24) dissolved in 200 ml of boiling water were added 1.0 g (0.012 mole) of sodium acetate and 0.7 g (0.01 mole) of hydroxylamine hydrochloride. The mixture was stirred and heated for 2 hours, then cooled to room temperature. The resulting precipitate was collected by filtration and when dried at 60° C. for 18 hours gave 0.7 g of the product of the Example as white crystals, mp 253°-255° C. (dec.).

1. temperatureheated for 2 hours
2. filtrationThe resulting precipitate was collected by filtration and when
3. customdried at 60° C. for 18 hours