(3-Methylpyridin-4-yl)methanamine → 1-[5-Methyl-2-(3-methyl-4-pyridinyl)-1H-imidazol-4-yl]ethanone

Participants

Reaction Conditions

Reaction Steps

A mixture consisting of 7.1 g (0.058 mole) of 3-methyl-4-pyridylmethylamine, 6.25 g (0.051 mole) of 2,3,4-pentanetrione 3-oxime, and 125 ml of acetonitrile was stirred at the reflux temperature for five hours. After cooling at -10° C., a precipitate formed. This was collected, washed with a little cold acetonitrile, and dried. Recrystallization from a mixture of chloroform and hexane gave 4.5 g of the desired product, mp 185°-187° C.

Provenance & Evidence