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HRID615384

反应详情

EQUATION

反应方程式

HRID 615384 的结构方程式

REACTANTS

反应物

2
结构：[NH4+].[OH-]
HCID14923

Ammonium hydroxide

H5NO

结构：Cc1cccc(C)c1NC(=O)CN1CCC(NCC(O)C2COc3ccccc3O2)CC1.Cl.Cl
HCID20427694

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cccc(C)c1NC(=O)CN1CCC(NCC(O)C2COc3ccccc3O2)CC1
HCID13393356

未命名化合物

收率 99.9%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A solution of 3.5 g of 4-{[2-(1,4-benzodioxan-2-yl)-2-hydroxyethyl]amino}-1-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperidine dihydrochloride salt in water (50 ml) is adjusted to pH 12 with ammonium hydroxide solution and extracted with methylene chloride. The methylene chloride is evaporated to afford 3 g of 4-{[2-(1,4-benzodioxan-2-yl)-2-hydroxyethyl]amino}-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperidine as the free base.

WORKUP

后处理

  1. extractionextracted with methylene chloride
  2. customThe methylene chloride is evaporated