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Triethylamine → N-(Butan-2-yl)-N-methyl-1-phenylisoquinoline-3-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | N-Methyl-2-butanamine | HCID 111026 | — |
| 反応物 | 1-Phenylisoquinoline-3-carboxylic acid | HCID 407896 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | N-(Butan-2-yl)-N-methyl-1-phenylisoquinoline-3-carboxamide | HCID 13272363 | 63.5% |
反応手順
Operations are carried out as for Example 7, starting with 2.96 g of 1-phenyl isoquinoline 3-carboxylic acid, 1.33 g of triethylamine, 1.49 g of ethyl chloroformate and 1.34 g of N-methyl 2-butanamine in 120 ml of chloroform. 2.4 g of N-methyl N(1-methyl propyl) 1-phenyl isoquinoline 3-carboxamide melting at 95°-96° C., are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04499094 |
| 出典データセット | uspto-grants-1985_02 |
| ORD ID | ord-b729fd781ac7454fb621227a888506ed |
| 出典メモ | uspto-grants-1985_02 |