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HRID615387

反应详情

EQUATION

反应方程式

HRID 615387 的结构方程式

REACTANTS

反应物

4
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：CCOC(=O)Cl
HCID10928

Ethyl chloroformate

C3H5ClO2

结构：CCC(C)NC
HCID111026

N-Methylbutan-2-amine

C5H13N

结构：O=C(O)c1cc2ccccc2c(-c2ccccc2)n1
HCID407896

3-Isoquinolinecarboxylic acid, 1-phenyl-

C16H11NO2

PRODUCTS

生成物

1
结构：CCC(C)N(C)C(=O)c1cc2ccccc2c(-c2ccccc2)n1
HCID13272363

N-(Butan-2-yl)-N-methyl-1-phenylisoquinoline-3-carboxamide

C21H22N2O

收率 63.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClC(Cl)Cl
溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

Operations are carried out as for Example 7, starting with 2.96 g of 1-phenyl isoquinoline 3-carboxylic acid, 1.33 g of triethylamine, 1.49 g of ethyl chloroformate and 1.34 g of N-methyl 2-butanamine in 120 ml of chloroform. 2.4 g of N-methyl N(1-methyl propyl) 1-phenyl isoquinoline 3-carboxamide melting at 95°-96° C., are obtained.