HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → [1-(2-Chlorophenyl)isoquinolin-3-yl](piperidin-1-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 3-Isoquinolinecarboxylicacid, 1-(2-chlorophenyl)- | HCID 11000554 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | [1-(2-Chlorophenyl)isoquinolin-3-yl](piperidin-1-yl)methanone | HCID 13272366 | 68.3% |
Reaction Steps
Operations are carried out as for Example 7, starting with 1.42 g of 1-(2-chlorophenyl) isoquinoline 3-carboxylic acid, 0.58 g of triethylamine, 0.62 g of ethyl chloroformate and 0.55 g of piperidine in 50 ml of chloroform. 1.2 g of 1-[[1-(2-chlorophenyl) 3-isoquinolyl]carbonyl]piperidine, melting at 161° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04499094 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-05cfd8a4714145f18052b43baff25812 |
| Source note | uspto-grants-1985_02 |