HRID615390

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8082

Piperidine

C5H11N

HCID8471

Triethylamine

C6H15N

HCID10928

Ethyl chloroformate

C3H5ClO2

HCID11000554

3-Isoquinolinecarboxylicacid, 1-(2-chlorophenyl)-

C16H10ClNO2

PRODUCTS

生成物

结构：O=C(c1cc2ccccc2c(-c2ccccc2Cl)n1)N1CCCCC1

HCID13272366

[1-(2-Chlorophenyl)isoquinolin-3-yl](piperidin-1-yl)methanone

C21H19ClN2O

收率 68.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

Operations are carried out as for Example 7, starting with 1.42 g of 1-(2-chlorophenyl) isoquinoline 3-carboxylic acid, 0.58 g of triethylamine, 0.62 g of ethyl chloroformate and 0.55 g of piperidine in 50 ml of chloroform. 1.2 g of 1-[[1-(2-chlorophenyl) 3-isoquinolyl]carbonyl]piperidine, melting at 161° C. is obtained.