HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-(sec-Butyl)-N-methyl-1-(thiophen-2-yl)isoquinoline-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | N-Methyl-2-butanamine | HCID 111026 | — |
| Reactant | 1-(Thiophen-2-yl)isoquinoline-3-carboxylic acid | HCID 13272395 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | N-(sec-Butyl)-N-methyl-1-(thiophen-2-yl)isoquinoline-3-carboxamide | HCID 13272380 | 65.6% |
Reaction Steps
Operations are carried out as for Example 7, starting from 3 g of 1-(2-thienyl) isoquinoline 3-carboxylic acid, 1.73 g of triethylamine, 1.86 g of ethyl chloroformate and 1.69 g of N-methyl 2-butanamine in 150 ml of chloroform. 2.5 g of N-methyl N-(1-methyl propyl) 1-(2-thienyl) isoquinoline 3-carboxamide, melting at 146° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04499094 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-22a6cf91fccc4bd68a54fea81b3b8254 |
| Source note | uspto-grants-1985_02 |