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HRID615397

反应详情

EQUATION

反应方程式

HRID 615397 的结构方程式

REACTANTS

反应物

4
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：CCOC(=O)Cl
HCID10928

Ethyl chloroformate

C3H5ClO2

结构：CCC(C)NC
HCID111026

N-Methylbutan-2-amine

C5H13N

结构：O=C(O)c1cc2ccccc2c(-c2cccs2)n1
HCID13272395

1-(Thiophen-2-yl)isoquinoline-3-carboxylic acid

C14H9NO2S

PRODUCTS

生成物

1
结构：CCC(C)N(C)C(=O)c1cc2ccccc2c(-c2cccs2)n1
HCID13272380

N-(Butan-2-yl)-N-methyl-1-(thiophen-2-yl)isoquinoline-3-carboxamide

C19H20N2OS

收率 65.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClC(Cl)Cl
溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

Operations are carried out as for Example 7, starting from 3 g of 1-(2-thienyl) isoquinoline 3-carboxylic acid, 1.73 g of triethylamine, 1.86 g of ethyl chloroformate and 1.69 g of N-methyl 2-butanamine in 150 ml of chloroform. 2.5 g of N-methyl N-(1-methyl propyl) 1-(2-thienyl) isoquinoline 3-carboxamide, melting at 146° C. are obtained.