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Dibutylamine → N,N-dibutyl 1-phenyl isoquinoline 3-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dibutylamine | HCID 8148 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | 1-Phenylisoquinoline-3-carboxylic acid | HCID 407896 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N,N-dibutyl 1-phenyl isoquinoline 3-carboxamide | HCID 20427637 | 41.5% |
反応手順
Operations are carried out as for Example 7, starting from 2.5 g of 1-phenyl isoquinoline 3-carboxylic acid, 1.15 g of triethylamine, 1.24 g of ethyl chloroformate and 1.66 g of dibutylamine in 100 ml of toluene. After chromatography and recrystallization in petroleum ether, 1.5 g of N,N-dibutyl 1-phenyl isoquinoline 3-carboxamide melting at 62° C. is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04499094 |
| 出典データセット | uspto-grants-1985_02 |
| ORD ID | ord-f1d271207d2244c4886c1a155473a2b5 |
| 出典メモ | uspto-grants-1985_02 |